Temperature-sensitive mutants of influenza virus
Identifieur interne : 002B68 ( Main/Exploration ); précédent : 002B67; suivant : 002B69Temperature-sensitive mutants of influenza virus
Auteurs : Susan B. Spring [États-Unis] ; Sandra R. Nusinoff [États-Unis] ; John V. Mills [États-Unis] ; Douglas D. Richman [États-Unis] ; Eveline L. Tierney [États-Unis] ; Brian R. Murphy [États-Unis] ; Robert M. Chanock [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1975.
Descripteurs français
- KwdFr :
- Animaux, Antigènes viraux (analyse), Bovins, Effets des rayonnements, Fluorouracil, Humains, Macaca mulatta, Mutagènes, Mutation, Méthode des plages virales, Orthomyxoviridae (croissance et développement), Rayons ultraviolets, Recombinaison génétique, Rein, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Techniques de culture, Température, Test de complémentation, Virus de la grippe A (croissance et développement), Virus de la grippe A (effets des radiations), Virus de la grippe A (immunologie).
- MESH :
- analyse : Antigènes viraux.
- croissance et développement : Orthomyxoviridae, Virus de la grippe A.
- effets des radiations : Virus de la grippe A.
- immunologie : Virus de la grippe A.
- Animaux, Bovins, Effets des rayonnements, Fluorouracil, Humains, Macaca mulatta, Mutagènes, Mutation, Méthode des plages virales, Rayons ultraviolets, Recombinaison génétique, Rein, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Techniques de culture, Température, Test de complémentation.
English descriptors
- KwdEn :
- Animals, Antigens, Viral (analysis), Cattle, Culture Techniques, Fluorouracil, Genetic Complementation Test, Humans, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus (growth & development), Influenza A virus (immunology), Influenza A virus (radiation effects), Kidney, Macaca mulatta, Mutagens, Mutation, Orthomyxoviridae (growth & development), Radiation Effects, Recombination, Genetic, Temperature, Ultraviolet Rays, Viral Plaque Assay.
- MESH :
- chemical , analysis : Antigens, Viral.
- growth & development : Influenza A virus, Orthomyxoviridae.
- immunology : Influenza A virus.
- radiation effects : Influenza A virus.
- Teeft :
- Animals, Assay, Cattle, Cell monolayers, Chanock, Chemical mutagenesis, Clone, Complementation, Complementation groups, Culture Techniques, Days postinfection, Different cistrons, Dual infection, Dually, Fluid medium, Fluorouracil, Form plaques, Genetic, Genetic Complementation Test, Genetic analysis, Genetic interaction, Genetic recombination, Genome, Hamster, Hemagglutinin, High efficiency, Higher temperature, Hirst, Host cell, Humans, Individual hamsters, Infectious virus, Influenza, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza virus, Influenza viruses, Inoculated, Input multiplicities, Kidney, Kilbourne, Lesion, Macaca mulatta, Monolayer cultures, Monolayers, Mutagenesis, Mutagens, Mutant, Mutant pairs, Mutation, Nasal turbinates, Permissive temperature, Plaque, Plaque formation, Poisson distribution, Preliminary characterization, Radiation Effects, Recombinant, Recombinant clones, Recombinant virus, Recombinant viruses, Recombination, Recombination, Genetic, Replication, Restrictive temperature, Restrictive temperatures, Revertant virus, Rollertube cultures, Serial dilutions, Shutoff, Shutoff temperature, Single lesion, Small number, Subset, Temperature, Temperature sensitivity, Tissue suspension, Turbinate, Ultraviolet Rays, Vaccine strain, Viable virus, Viral, Viral Plaque Assay, Virology, Virus, Virus genome, Virus suspension, Virus suspensions.
Abstract
Abstract: Temperature-sensitive genetic lesions were transferred from the ts-1 (H2N2) and ts-2 (H2N2) mutants of influenza A virus to wild-type influenza A (H3N2) virus by genetic reassortment. The ts-2 (H3N2) recombinants appeared to be homogeneous and did not undergo recombination with one another, suggesting that the original ts-2 mutant of influenza A (H2N2) contained a ts lesion(s) on only one RNA segment of its genome. In contrast the ts-1 (H3N2) recombinants fell into three phenotypic subsets which differed in degree of temperature sensitivity. Initially, the three subsets of ts-1 (H3N2) recombinants were thought to represent distinct complementation-recombination groups. However, complementation-recombination between the three subsets of ts-1 (H3N2) recombinants subsets was variable. Subsequent study indicated that mutants in each of the three subsets shared one ts lesion and two of the subsets shared an additional ts lesion. The mechanism whereby viruses of the three subsets which share one or two ts lesions, and nevertheless undergo apparent complementation-recombination on occasion is not understood.
Url:
- https://api.istex.fr/ark:/67375/6H6-GJ15HX7G-G/fulltext.pdf
- https://api.istex.fr/ark:/67375/6H6-SVH8V3J0-8/fulltext.pdf
DOI: 10.1016/0042-6822(75)90224-X
Affiliations:
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Le document en format XML
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Spring</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Nusinoff, Sandra R" sort="Nusinoff, Sandra R" uniqKey="Nusinoff S" first="Sandra R" last="Nusinoff">Sandra R. Nusinoff</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Mills, John V" sort="Mills, John V" uniqKey="Mills J" first="John V" last="Mills">John V. Mills</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Richman, Douglas D" sort="Richman, Douglas D" uniqKey="Richman D" first="Douglas D" last="Richman">Douglas D. Richman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Tierney, Eveline L" sort="Tierney, Eveline L" uniqKey="Tierney E" first="Eveline L" last="Tierney">Eveline L. Tierney</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R" last="Murphy">Brian R. Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M" last="Chanock">Robert M. Chanock</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1975">1975</date><biblScope unit="volume">66</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="522">522</biblScope><biblScope unit="page" to="532">532</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Viral (analysis)</term><term>Cattle</term><term>Culture Techniques</term><term>Fluorouracil</term><term>Genetic Complementation Test</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (growth & development)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (radiation effects)</term><term>Kidney</term><term>Macaca mulatta</term><term>Mutagens</term><term>Mutation</term><term>Orthomyxoviridae (growth & development)</term><term>Radiation Effects</term><term>Recombination, Genetic</term><term>Temperature</term><term>Ultraviolet Rays</term><term>Viral Plaque Assay</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antigènes viraux (analyse)</term><term>Bovins</term><term>Effets des rayonnements</term><term>Fluorouracil</term><term>Humains</term><term>Macaca mulatta</term><term>Mutagènes</term><term>Mutation</term><term>Méthode des plages virales</term><term>Orthomyxoviridae (croissance et développement)</term><term>Rayons ultraviolets</term><term>Recombinaison génétique</term><term>Rein</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Techniques de culture</term><term>Température</term><term>Test de complémentation</term><term>Virus de la grippe A (croissance et développement)</term><term>Virus de la grippe A (effets des radiations)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes viraux</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Orthomyxoviridae</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Influenza A virus</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Animals</term><term>Assay</term><term>Cattle</term><term>Cell monolayers</term><term>Chanock</term><term>Chemical mutagenesis</term><term>Clone</term><term>Complementation</term><term>Complementation groups</term><term>Culture Techniques</term><term>Days postinfection</term><term>Different cistrons</term><term>Dual infection</term><term>Dually</term><term>Fluid medium</term><term>Fluorouracil</term><term>Form plaques</term><term>Genetic</term><term>Genetic Complementation Test</term><term>Genetic analysis</term><term>Genetic interaction</term><term>Genetic recombination</term><term>Genome</term><term>Hamster</term><term>Hemagglutinin</term><term>High efficiency</term><term>Higher temperature</term><term>Hirst</term><term>Host cell</term><term>Humans</term><term>Individual hamsters</term><term>Infectious virus</term><term>Influenza</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza virus</term><term>Influenza viruses</term><term>Inoculated</term><term>Input multiplicities</term><term>Kidney</term><term>Kilbourne</term><term>Lesion</term><term>Macaca mulatta</term><term>Monolayer cultures</term><term>Monolayers</term><term>Mutagenesis</term><term>Mutagens</term><term>Mutant</term><term>Mutant pairs</term><term>Mutation</term><term>Nasal turbinates</term><term>Permissive temperature</term><term>Plaque</term><term>Plaque formation</term><term>Poisson distribution</term><term>Preliminary characterization</term><term>Radiation Effects</term><term>Recombinant</term><term>Recombinant clones</term><term>Recombinant virus</term><term>Recombinant viruses</term><term>Recombination</term><term>Recombination, Genetic</term><term>Replication</term><term>Restrictive temperature</term><term>Restrictive temperatures</term><term>Revertant virus</term><term>Rollertube cultures</term><term>Serial dilutions</term><term>Shutoff</term><term>Shutoff temperature</term><term>Single lesion</term><term>Small number</term><term>Subset</term><term>Temperature</term><term>Temperature sensitivity</term><term>Tissue suspension</term><term>Turbinate</term><term>Ultraviolet Rays</term><term>Vaccine strain</term><term>Viable virus</term><term>Viral</term><term>Viral Plaque Assay</term><term>Virology</term><term>Virus</term><term>Virus genome</term><term>Virus suspension</term><term>Virus suspensions</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Bovins</term><term>Effets des rayonnements</term><term>Fluorouracil</term><term>Humains</term><term>Macaca mulatta</term><term>Mutagènes</term><term>Mutation</term><term>Méthode des plages virales</term><term>Rayons ultraviolets</term><term>Recombinaison génétique</term><term>Rein</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Techniques de culture</term><term>Température</term><term>Test de complémentation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Temperature-sensitive genetic lesions were transferred from the ts-1 (H2N2) and ts-2 (H2N2) mutants of influenza A virus to wild-type influenza A (H3N2) virus by genetic reassortment. The ts-2 (H3N2) recombinants appeared to be homogeneous and did not undergo recombination with one another, suggesting that the original ts-2 mutant of influenza A (H2N2) contained a ts lesion(s) on only one RNA segment of its genome. In contrast the ts-1 (H3N2) recombinants fell into three phenotypic subsets which differed in degree of temperature sensitivity. Initially, the three subsets of ts-1 (H3N2) recombinants were thought to represent distinct complementation-recombination groups. However, complementation-recombination between the three subsets of ts-1 (H3N2) recombinants subsets was variable. Subsequent study indicated that mutants in each of the three subsets shared one ts lesion and two of the subsets shared an additional ts lesion. The mechanism whereby viruses of the three subsets which share one or two ts lesions, and nevertheless undergo apparent complementation-recombination on occasion is not understood.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Spring, Susan B" sort="Spring, Susan B" uniqKey="Spring S" first="Susan B" last="Spring">Susan B. Spring</name></region><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M" last="Chanock">Robert M. Chanock</name><name sortKey="Mills, John V" sort="Mills, John V" uniqKey="Mills J" first="John V" last="Mills">John V. Mills</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R" last="Murphy">Brian R. Murphy</name><name sortKey="Nusinoff, Sandra R" sort="Nusinoff, Sandra R" uniqKey="Nusinoff S" first="Sandra R" last="Nusinoff">Sandra R. Nusinoff</name><name sortKey="Richman, Douglas D" sort="Richman, Douglas D" uniqKey="Richman D" first="Douglas D" last="Richman">Douglas D. Richman</name><name sortKey="Tierney, Eveline L" sort="Tierney, Eveline L" uniqKey="Tierney E" first="Eveline L" last="Tierney">Eveline L. Tierney</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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